The Israeli military says a rocket was launched early Monday from the Gaza Strip towards Israel.
Police and medics said a house was on fire and six people were wounded.
The incident in Mishmeret, an agricultural town north of Tel Aviv, came at a time of high tension ahead of the anniversary of Gaza border protests and an April 9 election campaign in Israel.
The attack also comes 10 days after rockets were fired towards Tel Aviv. Gaza’s Hamas leaders said they were fired accidently.
There was no immediate claim of responsibility for Monday’s incident. Explosions were heard in central Israel as air raid sirens wailed.
The Magen David Adom ambulance service said it was treating six of the building’s occupants for wounds. That came minutes after the Israeli military activated air raid sires in the area and said one rocket had been launched.
Gaza is controlled by Hamas. The territory is home to other armed groups, including Islamic Jihad, an Iranian-backed organisation that also has a formidable rocket arsenal.
Israeli Prime Minister Benjamin Netanyahu, who is seeking a fifth term in next month’s ballot, was in Washington on Monday and due to meet US President Donald Trump.